There are several products claiming to have health benefits of CBD with 10 or 20mg capsule. However, without taking into account of the xenobiotic metabolism, microbial enteric activity and bioavailability of CBD, they are just selling ineffective products.
Cannabinoid receptorsare highly expressed on enteric nerves and throughout the intestinal mucosa on entero-endocrine cells (CB1), immune cells (CB1and CB2) and enterocytes (CB1and CB2). Further GI tract is the primary site where the CBD is mainly absorbed into the systemic circulation for central and peripheral nervous system functions.
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